Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant
نویسندگان
چکیده
Metastatic melanoma is frequently treated with immune activating therapy, which poses a theoretical risk of inducing graft versus host disease (GVHD) in those who have received allogeneic stem cell transplantation. The literature reporting the safety of immunotherapy in post transplant patients is limited. We report two patients with metastatic melanoma who received treatment with immunotherapy after allogeneic stem cell transplantation that did not result in GVHD.
منابع مشابه
High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation.
Clinical application of allogeneic bone marrow transplantation (BMT) has been limited by toxicity related to cytoreductive conditioning and immune response. In utero hematopoietic stem cell transplantation (IUHSCT) is a nonablative approach that achieves mixed chimerism and donor-specific tolerance but has been limited by minimal engraftment. We hypothesized that mixed chimerism achieved by IUH...
متن کاملImaging in Bone Marrow Transplantation.
Bone marrow transplantation (BMT) is a technique used in the treatment of leukemia, lymphoma, aplastic anemia, multiple myeloma, immune deficiency disorders, and certain solid tumors such as breast and ovarian carcinoma. It is a salvage technique that permits high-dose, myelosuppressive chemotherapy to be given, achieving greater response rates to therapy. After giving high-dose therapy, treati...
متن کاملA 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Objectives: Graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays Cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. Cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...
متن کاملA 16 Month Survey of Cyclosporine Utilization Evaluation in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Objectives: Graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays Cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. Cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...
متن کاملSevere disseminated toxoplasmosis after unrelated bone marrow transplantation: a case report.
1. De Renzo A, Pezzullo L, D'Arco A, et al. A five drug regimen (VEBEP) followed by involved field radiotherapy in the treatment of Hodgkin's disease [abstract]. Blood 1998; 92(Suppl. 1):235b (abs. 4009). 2. Flowers MED, Sullivan KM, Martin P, et al. G-CSF stimulated donor peripheral blood infusions as immunotherapy in patients with hematologic malignancies relapsing after allogeneic transplant...
متن کامل